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The article is focused on the thermal behaviour of a spindle of a milling centre. This is a typical problem of high precision machines, which produce heat as a negative implication of production activity. Thermal loading influents productivity and precision of milling centre. Thermal transfer simulations, computed fluid dynamic solutions and finite element methods in general are vital sources of information about behaviour of machine parts influenced by heat loading. Reduction of thermal displacement is a crucial task. The sensitivity study, based on a complex case study, is able to identify features with significant influence on overall deformation. Complex case consists of detail subcase analysis. Identified parts require modifications to decrease of deformations. Results are compared with new productive computation method based on macro-models. Combination of these methods defines productive methodology which leads to fast prediction and accurate simulation.