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Reducing the driving force when propelling a wheelchair, eg through mechanical gears, is beneficial for people using wheelchairs. This makes it possible to overcome terrain obstacles that would be impossible to overcome with a classic drive system. However, the disadvantage of additional mechanisms supporting the propulsion of the wheelchair is usually the additional rolling resistance. The article presents methods of measuring the rolling resistance, which are widely developed in the automotive industry in terms of measuring the rolling resistance of wheelchairs. Innovative methods have been demonstrated to measure the rolling resistance on various surfaces and with the use of various drive mechanisms. The developed methods also enable the determination of the rolling resistance coefficient.