The ball screws are characterized with better positioning accuracy and higher efficiency and load ratings than the same size lead screw, but still cannot fully replace their functionality mostly due to the self-locking. Leads screws are recommended especially for such applications as grippers, lifters, presses and vertical positioning drives. By proper selection of the lead screw geometrical features and application of the modern materials, it is possible to obtain much more advantageous parameters of the drive system. In this paper, the methodology of optimization of the drive mechanism with lead screw using Isight software is presented. The performed sensitivity analysis allowed not only to find the influence of various constructional features such as: size of the thread, length of the screw and material properties, on the maximum load capacity of the drive mechanism and its inertia, but also determine its scale impact. The obtained results can improve the design process of lead screw mechanism.